Phellinus linteus cancer research – Research for Phellinus linteus

A) Antitumor effect

5.) 2002 – The roles of ERK 1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against theinhibition of gap junctional intercellular communication by hydrogen peroxide

6.) 2002 – Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides

7.) 2003 – Acidic polysaccharides isolated from Phellinus linteus induces nitric oxide-mediated tumoricidal activity of macrophages through protein tyrosine kinase and protein kinase C

8.) 2003 – Acidic polysaccharides isolated from Phellinus linteus induce phenotypic and functional maturation of murine dendritic cells

9.) 2003 – Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus

10.) 2003 – Proteoglycan isolatd from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase

11.) 2003 – Purification and characterization of acidic proteo-heteroglycan from the fruiting body of Phellinus linteus (Berk. & M.A.Curtis) Teng

12.) 2004 – Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-α from peritoneal macrophages

13.) 2004 – Fractionation and anti-tumot activity of the mycelia of lliquid-cultured Phellinus linteus

14.) 2004 – Proteoglycan isolatd from Phellinus linteus induces toll-like receptors 2-and 4-mediated maturation of murine dendritic cells via activation of ERK, p38 and NF-KB

15.) 2004 – Proteoglycan isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c⁺CD8⁺ DC and type I helper T cell -dominant immue state

16.) 2005 – Cambodian Phellinus linteus inhibits expertimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator

17.) 2005 – Inhibition of IgE-dependent mouse triphasic cutaneous reaction by a boiling water fraction seperated from mycelium of Phellinus linteus

18.) 2006 – Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion

19.) 2008 – Antiproliferative and antimetastatic effects of the ethanolic extract of Phellinus igniarius (Linnearus:Fries) Quelet

20.) 2009 – Anti-cancer activities of Ginseng extract fermented with Phellinus linteus

21.) 2010 – Medicinal mushroom Phellinus linteus as an alternative cancer therapy (Review)

22.) 2012 – Hispidin produced from Phellinus linteus protects against peroxynitrite-mediated DNA damage and hydroxyl radical generation

23.) 2013 – Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice

24.) 2015 – “Potent anticancer effects of bioactive mushroom extracts (Phellinus linteus) on a variety of human cencer cells

B) Apoptosis effect

1.) 2003 – Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellnus linteus

2.) 2008 – Pro- and antioxidative properties of medicinal mushroom extracts

C) Bladder cancer

1.) 2009 – Hispolon from Phellinus linteus has antiproliferative effects via MEM2-recruited ERK1/2 activitiy in breast and bladder cancer

D) Breast cancer

1.) 2008 – Phellinus linteus suppress growth, angigogenesis and invasive behavior of breast cancer cells through the inhibition of AKT signalling

2.) 2009 – Hispolon from Phellinus linteus has antiproliferative effects via MEM2-recruited ERK1/2 activitiy in breast and bladder cancer

3.) 2012 – Biological activities of natural Phellinus SPP. mushroom in human cancer cells

E) Colon cancer

1.) 2004 – Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells

2.) 2009 – Anti tumor effects and imminomidulating activities of Phellinus linteus extract in a CT-26 cell-injected colon cancer mouse model

3.) 2013 – Activation of P27kip 1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells

F) Gastric cencer

1.) 1997 – “근치 적 위 절제술을 시행받은 위암 환자에서 상황 (메시 마-엑스)의 항 종양 효과 (Antitumor effect of the situation (Messima-X) in gastric cancer patients undergoing curative gastrectomy)”

2.) 2008 – Hispolon induces apoptosis in huma gastric cancer cells through a ROS-mediated mitochondrial pathway

G) Kidney

1.) 2019 – Involvement of Up-regulation of death receptors and Bim in hispolon-mediated TNF-related apoptosis-inducing ligand sensitization in human renal carninoma

H) Leukemia

1.) 2010 – Extracts of medicinal mushrooms Agaricus bisporus and Phellinus linteus induce proapoptotic effects in the human leukemia cell line K562

2.) 2013 – “Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukemia cells”

I) Liver cancer

1.) 2003 – Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats

2.) 2003 – Inhibition of cytochrome P540 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus

3.) 2004 – Mycelial culture of Phellinus linteus protects primary cultured rat hepatocytes against hepatoxins

4.) 2005 – Spontaneous regression of a large hepatocellular carcinoma with skull metastasis

5.) 2007 – Protective effects of Phellinus linteus extract against iron overload-medicated oxidative steress in cultured rate hepatocytes

6.) 2008 – Antagonizing TGF-β induced liver fibrosis by a retinoic acid derivative through regulation of ROS and calcium influx

7.) 2008 – Inhibition of transforming growth factor-β-induced liver fibrosis by a retinoic acid derivative via suppression of Col 1A2 promoter activity

8.) 2009 – Tumor-inhibitory and liver-protective effects of Phellinus igniarius extracellular polysaccharides

9.) 2011 – Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice

10.) 2012 – “Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide induced liver fibrosis in rats: a proteomics analysis “

11.) 2014 – Different immunology mechanisms of Phellinus igniarius in inhibiting growth of liver cancer melanoma cells

J) Lung cancer

1.) 2006 – A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases

2.) 2006 – Mycelial extract of Phellinus linteus induces cell death in A549 lung cancer cells and elevation of nitric oxide in Raw 264.7 macrophage cells

3.) 2007 – Inhibitory effect of oral intake of natural Phellinus linteus fruit body on growth and pulmonary metastasis of B16/BL6 melanoma

4.) 2007 – Modulation of lung cancer growth arrest and apoptosis by Phellinus linteus

5.) 2008 – Phellifuropyranone A: A new furopyranone compound isolated from fruit bodies of wild Phellinus linteus

6.) 2011 – Inhibitory effect of oral administration of Sangwhang mushroom (Phellinus linteus) grown on germinated brown rice on experimental lung metastasis and tumor growth in mice

K) Lymphoma

1.) 2006 – Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus

L) Neuroblastome cancer

1.) 2004 – Induction of apoptotic cell death by mycelium extracts of Phellinus linteus in human neuroblastoma cells

M) Oral cancer

1.) 2006 – The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis) Teng on human epidermoid KB cells

N) Pancreayic cancer

1.) 2004 – Improvement insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats

2.) 2013 – Anticancer effect of Phellinus linteus; potential clinical application in treating pancreactic ductal adenocarcinoma

O) Prostate cancer

1.) 2003 – Dramatic remission of hormone refractory prostate cancer achieved with extract of the mushroom, Phellinus linteus

2.) 2005 – Administration of extract of mushroom Phellinus linteus induces prostate enlargement with increase in stromal component in experimentally developed rat model of benign prostatic hyperplasia

3.) 2006 – Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer

4.) 2007 – Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells

5.) 2010 – Phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice

P) Skull cancer

1.) 2005 – Spontaneous regression of a large hepatocellular carcinoma with skull metastasis